(S)-2-Amino-3-[(1,2-dioxo-2-hydroxyethyl)amino]propionic acid
β-n-oxalylamino-l-alanine
CAS: 5302-45-4
Molecular Formula: C5H8N2O5
(S)-2-Amino-3-[(1,2-dioxo-2-hydroxyethyl)amino]propionic acid - Names and Identifiers
(S)-2-Amino-3-[(1,2-dioxo-2-hydroxyethyl)amino]propionic acid - Physico-chemical Properties
| Molecular Formula | C5H8N2O5 |
| Molar Mass | 176.13 |
| Density | 1.596±0.06 g/cm3 (20 ºC 760 Torr) |
| Specific Rotation(α) | -36.9 (c, 0.66 in 4N HCl) |
| Solubility | H2O : 5 mg/mL (28.39 mM; Need ultrasonic);DMSO : 5 mg/mL (28.39 mM; Need ultrasonic) |
| Appearance | Colorless crystal |
| Color | white to beige |
| pKa | 1.99±0.10(Predicted) |
| Storage Condition | Keep in dark place,Sealed in dry,2-8°C |
| MDL | MFCD00055228 |
| Physical and Chemical Properties | Colorless crystal, soluble in methanol, ethanol, DMSO and other organic solvents, derived from the dried root of Panax notoginseng. |
| In vitro study | Dencichin (β-ODAP, 10 μM, 50 μM, 100 μM and 200 μM) increases HRE expression by 1.3±0.09, 2.5±0.07, 4.2±0.15 and 1.3±0.07 fold respectively compared to control. Dencichin has intermolecular interactions with PHD-2. Dencichin (10 μM, 100 μM, 1 mM) significantly inhibits cell proliferation and extracellular matrix (ECM) proteins accumulation of HBZY-1 cells, and reduces the secretion of collagen I (Col I), collagen IV (Col IV), and fibronectin (FN). |
| In vivo study | Dencichin improves metabolism disorder in diabetic nephropathy (DN) secondary to type II diabetes mellitus (DM) model. Dencichin (80, 160 mg/kg/day, p.o.) significantly prevents the up-regulation of TCH, TG, LDL, and HbAlc and the down-regulation of HDL in DN rats induced by STZ injection. Dencichin also attenuates renal injury induced in the DN secondary to type II DM model. Dencichin alleviates pancreas damage in the STZ-induced DN model. Dencichin regulates protein expression in the TGF-β/Smad signalling pathway in STZ-induced DN models. |
(S)-2-Amino-3-[(1,2-dioxo-2-hydroxyethyl)amino]propionic acid - Reference
| Reference Show more | 1. Liu Yong, Xu Na, Chen Junfei et al. Effects of different drying methods on appearance, internal structure and quality of Panax notoginseng [J]. Chinese herbal medicine, 50 Vol. 23, 57, 14-57, 23 pages ISTIC PKU CSCD CA 2020. 2. Wang Rong-rong et al. [IF = 1.978]. "Acute Developmental scale of pantax notoginsen in zebra fish Larvae." Chin J Integr Med. 2022 Jan;:1-8 |
(S)-2-Amino-3-[(1,2-dioxo-2-hydroxyethyl)amino]propionic acid - Introduction
Β-N-oxalylamino-L-alanine, also known as twenty-six betel nut liquid, is an organic compound with the chemical formula C27H44O10. The following is a description of the properties, uses, preparation and safety information of β-N-oxalylamino-L-alanine:
Nature:
-Appearance: β-N-oxalylamino-L-alanine is in the form of a white to yellow crystalline powder.
-Melting point: β-N-oxalylamino-L-alanine has a high melting point, about 215-218 degrees Celsius.
-Solubility: Poor solubility in water, but more soluble in organic solvents.
Use:
-Medicinal: β-N-oxalylamino-L-alanine has antibacterial, anti-inflammatory and antioxidant activities. It is widely used in the field of traditional Chinese medicine and can be used to treat cardiovascular and cerebrovascular diseases, cancer, diabetes and other diseases.
-Food additives: β-N-oxalylamino-L-alanine can also be used as a food additive to provide natural antibacterial and antioxidant properties.
Preparation Method:
- β-N-oxalylamino-L-alanine is usually obtained by extraction from the rhizome of Panax notoginseng. The extraction method can be carried out using a solvent such as water, ethanol or dichloromethane.
Safety Information:
- β-N-oxalylamino-L-alanine is generally regarded as safe when used properly or under medical supervision. However, the following matters still need to be noted:
-Avoid inhalation or contact with β-N-oxalylamino-L-alanine powder. Wear gloves and a mask.
-Children need to be kept away and stored in a dry, ventilated place away from fire sources.
-Due to individual differences and dosage restrictions, consult a doctor or professional before use.
Nature:
-Appearance: β-N-oxalylamino-L-alanine is in the form of a white to yellow crystalline powder.
-Melting point: β-N-oxalylamino-L-alanine has a high melting point, about 215-218 degrees Celsius.
-Solubility: Poor solubility in water, but more soluble in organic solvents.
Use:
-Medicinal: β-N-oxalylamino-L-alanine has antibacterial, anti-inflammatory and antioxidant activities. It is widely used in the field of traditional Chinese medicine and can be used to treat cardiovascular and cerebrovascular diseases, cancer, diabetes and other diseases.
-Food additives: β-N-oxalylamino-L-alanine can also be used as a food additive to provide natural antibacterial and antioxidant properties.
Preparation Method:
- β-N-oxalylamino-L-alanine is usually obtained by extraction from the rhizome of Panax notoginseng. The extraction method can be carried out using a solvent such as water, ethanol or dichloromethane.
Safety Information:
- β-N-oxalylamino-L-alanine is generally regarded as safe when used properly or under medical supervision. However, the following matters still need to be noted:
-Avoid inhalation or contact with β-N-oxalylamino-L-alanine powder. Wear gloves and a mask.
-Children need to be kept away and stored in a dry, ventilated place away from fire sources.
-Due to individual differences and dosage restrictions, consult a doctor or professional before use.
Last Update：2024-04-09 20:45:29
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Spot supply
Product Name: β-n-oxalylamino-l-alanine Visit Supplier Webpage Request for quotationCAS: 5302-45-4
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Wechat: 18301782025
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